The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a little soluble in Alcoholic beverages. The molecular fat is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it has the subsequent chemical construction.
Promethazine with Codeine Oral Remedy is a mix of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated to the non permanent reduction of cough and upper respiratory indications associated with allergy or perhaps the common cold in clients 18 several years of age and more mature.
Although the possibility of addiction in almost any individual is not known, it could possibly occur in clients properly prescribed Promethazine with Codeine Oral Option. Addiction can take place at advisable dosages and When the drug is misused or abused. Challenges are greater in sufferers with a private or relatives record of substance abuse (such as drug or Alcoholic beverages abuse or addiction) or mental illness (eg., key melancholy).
The codeine and promethazine in Promethazine with Codeine Oral Remedy may perhaps boost the frequency of seizures in patients with seizure disorders, and should improve the threat of seizures developing in other medical settings affiliated with seizures.
Because of the potential for promethazine to reverse epinephrine’s vasopressor effect, epinephrine really should not be applied to deal with hypotension linked with promethazine overdose.
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This medication may possibly comprise sugar and/or Liquor. Caution is encouraged When you have diabetes, Alcoholic beverages dependence, or liver disorder. Inquire your doctor or pharmacist about utilizing this item safely and securely.
This medication website might make you far more sensitive for the Sunshine. Limit your time in the Sunshine. Steer clear of tanning booths and sunlamps. Use sunscreen and don protective outfits when outdoor. Explain to your physician immediately if you receive sunburned or have skin blisters/redness.
Codeine has excellent antitussive exercise, Though under that of morphine at equivalent doses. It is used in preference to morphine, since Uncomfortable side effects are rare at the same old antitussive dose of codeine.
Warning For all individuals taking this medicine: This medication has an opioid drug in it. Opioid medications can place you in danger for addiction, abuse, and misuse. Misuse or abuse of promethazine and codeine can cause overdose and Loss of life. When you have issues, converse with your health care provider. This medicine has an opioid drug in it. Extreme Unwanted effects have took place when opioid medication had been utilised with benzodiazepines or other medication that may make you drowsy or slow your steps. This includes gradual or troubled respiration and Loss of life. Benzodiazepines consist of medicine like alprazolam, diazepam, and lorazepam. Benzodiazepines may very well be utilised to take care of several medical problems like panic, difficulties sleeping, or seizures. If you have queries, converse with your health practitioner. Several prescription drugs interact with promethazine and codeine and can increase the possibility of Unwanted side effects like lethal respiration problems. Discuss with your health practitioner and pharmacist to make sure it really is Safe and sound to employ promethazine and codeine with all of your medication. Stay away from Liquor or other medicines and normal products that sluggish your actions.
Codeine will cause miosis, even in complete darkness. Pinpoint pupils are an indication of opioid overdose but aren't pathognomonic (eg, pontine lesions of hemorrhagic or ischemic origins may deliver very similar conclusions). Marked mydriasis in lieu of miosis may be seen because of hypoxia in overdose circumstances.
Postmarketing conditions of respiratory depression, like fatalities, are already documented with usage of promethazine in pediatric people. Concomitant administration with other respiratory depressants may perhaps enhance the threat of respiratory melancholy.
Codeine wasn't mutagenic in the in vitro bacterial reverse mutation assay or clastogenic during the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Inform clients that a home teaspoon just isn't an correct measuring product and these kinds of use could lead on to overdosage and significant adverse reactions [see OVERDOSAGE (10)]. For prescriptions wherever a measuring gadget is not really presented, a pharmacist can offer an appropriate calibrated measuring unit and can provide Guidelines for measuring the right dose.